Along with food processing, the production of agro-industrial waste in the world increases, despite the fact that it is a rich source of nutrients and bioactive compounds. In developing countries, waste materials from the agricultural industry can significantly help in obtaining valuable components for the production of various types of bio-based products. The aim of the work is to manage potato peel waste from the agri-food processing industry and to propose new nutritional and industrial applications for them. Food processing by-products are an inexpensive, affordable, and valuable starting material for the extraction of value-added products such as dietary fiber, natural antioxidants, biopolymers, and natural food additives. Potato peel waste, which is produced by various processes, such as extraction, fermentation, and other processes, can be transformed into products such as biofuels, dietary fiber, bio-fertilizers, biogas, biosorbent, antioxidants and various food additives. This work explores the use of potato skins as a source of nutraceuticals for food and non-food purposes, e.g., extraction, use of bioactive ingredients, biotechnological use, livestock feed and other applications. The practical approach will be able to be used in developing awareness of the proper management of agricultural waste, as well as in their application for the synthesis of many compounds such as lactic acid, biosorbent, biohydrogen, enzymes, etc., which serve as a basis for developing links between industry and sharing with new ideas and technologies