Wound infections in animals are polymicrobial, with a broad mixture of aerobic and anaerobic organisms. Bacteria recovered from infected wounds most often originate from the environment, including soil, plants, dust, and manure contaminating injured soft tissues, are part of the skin microbiome and may also reflect the microflora of the biting animals. Pure anaerobic growth is among rare cases. The most common causative organisms staphylococci, streptococci, enterococci and Pseudomonas aeruginosa. Surgical site infections are among nosocomial cases in dogs and cats. and the concern in veterinary clinics is the growing number of multidrug-resistant pathogens. Organisms such as methicillin-resistant staphylococci, extended spectrum β-lactamase Enterobacteriaceae and multi-drug resistant Enterococcus, Acinetobacter and Pseudomonas spp., are among the serious practical concerns. Apart from local ailment, systemic, wounds originated bacterial infections, can develop: tetanus, malignant oedema, footrot. This paper aims at the presentation of major and often recognized organisms that may cause severe health problems to injured animals.