Transboundary animal diseases (TADs), are highly contagious and epidemic diseases that can spread extremely fast, irrespective of national borders and cause high animals death rates. They have serious socio-economic and public health consequences and they affect food and nutrition security, global livestock production and seriously disrupt or inhibit livestock and livestock products trade at either national or international level. Globalization, climate changes and land encroachment contribute to outbreaks of devastating animal diseases. TADs include also diseases transmissible to humans (brucellosis, bovine spongiform encephalopathy, MERS, Nipah), and high-impact animal diseases (peste des petites ruminants, African swine fever, Newcastle disease, Schmallenberg disease, bluetongue, African horse sickness). There are evidences suggesting that threats from TADs have increased over the years. The risk of animal disease outbreaks is likely to further grow in future as the higher incomes in developing countries will generate growing humans demand for animal protein and animal derived products. This article provides the experience gained in the control and management of important transboundary diseases along with the successes, constraints, limitations and future research needs for developing better control approaches.