In the present study, imperative parameters including centrifugal force, erosion, streamline, strain rate, and wall shear are evaluated in a cyclone separator. The flaw of the cyclone surface due to erosion is an acute problem in the industry. According to the great importance of the centrifugal force on the separation phenomenon, a comprehensive study is conducted. A computational fluid dynamics (CFD) simulation is realized by applying a Reynolds stress turbulence model (RSM), and particle–air interactions were modeled using a discrete phase model (DPM). The result shows a good agreement between the experimental data and CFD simulation on the tangential velocity and pressure drop. The maximum deviation of the validation process is 6.8%. It is found that the centrifugal force within the cyclone is increased with an enhancement in the inlet velocity. The separation efficiency indicates an increase–decrease treatment in various inlet velocities with inlet velocity up to 16 m⋅s−1 but decreases slightly at a velocity of 20 m⋅s−1. The pressure increases proportionally with inlet velocity. The best performance with the highest separation efficiency (99%) and pressure drop (416 Pa) obtains at the inlet velocity of 16 m⋅s−1 and mass flow rate of 0.01 kg⋅s−1. In addition, the maximum erosion rate was created in the entrance and conical part of the cyclone.