Atmospheric drought is an extremely important issue on a global, regional and local scale, especially in the context of climate change. The aim of the study was to assess the spatiotemporal variation of atmospheric (meteorological) drought in agricultural areas of east-central Poland, represented by the Lublin Voivodeship (Lublin region) in 1971–2015. Average monthly air temperatures and monthly precipitation totals recorded over the 45-year period at 25 weather stations were used in the study. The assessment of spatiotemporal variation in atmospheric drought in the study area was based on calculations of the aridity index. The analysis showed an increase in the severity of atmospheric drought in the Lublin region, with intensification of this phenomenon in the last two decades, especially in the warmer half of the year (April, June–August). The main cause of drought in the Lublin region was identified as a statistically significant increase in air temperature (on average, from 0.4 °C to 0.7 °C/10 years in April, July and August, and from 0.2 °C to 0.5 °C/10 years in June) together with the absence of changes in precipitation in the warmer half of the year. This may be linked to some increase in the frequency of high-pressure circulation types, both non-directional and advection from the south. Due to the worsening problem of drought in Poland in recent years, especially in agriculture, there is a need for further research on this subject and for solutions aimed at optimizing agricultural use of the productive environment.