The article presents the research made on the effects of methods of pressure-thermal agglomeration of corn bran, as well as the influence of processing parameters on selected physicochemical properties and biogas efficiency. Corn bran moistened to four levels of moisture content was used for the tests: 20%, 25%, 30% and 35% of dry matter. The pressure-thermal treatment was carried out with the use of a Brikol SJ25 pellet maker and a TS-45 single-screw extruder. In the tests of the extrusion-cooking process, three rotational speeds of the extruder screw were applied: 70, 90 and 110 rpm. The following characteristics were examined: efficiency of the extrusion-cooking and pelleting process, as well as the energy consumption. The water absorption index (WAI), the water solubility index (WSI), bulk density, kinetic strength, structure analysis by the ART/FTIR method, energy potential and the efficiency of cumulated biogas and cumulated methane per dry mass, as well as fresh mass and fresh organic matter and a series of microscopic pictures were completed. The analysis of the ATR/FTIR infrared spectra of the tested pelleted and extruded samples showed clear changes at the molecular level. Biogas production of extruded corn bran increased by several percent, as compared to untreated material.