We report the experimental results of tests aimed at assessing the effects of different settings on the mean radius of mineral fertilizer distribution using a disc fertilizer spreader. Our aim was to improve the performance of fertilizer distribution in sustainable agriculture. Three types of mineral fertilizers with different physical characteristics, commonly used in agriculture, were considered: urea, calcium ammonium nitrate and ammonium sulfate. A complete randomization method based on a four-factor experimental model was used to study the influence of the functional and operational parameters on the mean radius of fertilizer spread. Fixed model analysis of variance showed that fertilizer type, vane configuration and disc angular velocity explained 91.74% of the variance of the spread mean radius, while linear multiple regression analysis highlighted that the fertilizer dust fraction and disc angular velocity had an overall effect of 82.72%, the former showing an inverse correlation as high as 72.77%.