Two novel Cu(II) and Zn(II) complexes with 1,3,4-thiadiazoles were obtained under mild reaction conditions. The structures of free ligands and the corresponding complexes were characterized by spectroscopic methods. The biol. activity of all compds. was estd. by detn. of their antioxidant and antibacterial activities against bacterial species. The complexes showed relatively high soly. in aq. solns. Both the free ligands and their Cu(II) and Zn(II) complexes exhibited a moderate antioxidant and antibacterial activities.