Ghrelin (GHRL) and uncoupling proteins UCP2, UCP3 playa functional role in global energy metabolism in the body, growth and obesity as well as meat organoleptic quality. The aim of this study was to analyze homology between the regions of human chromosomes involving the encoding lociGHRL, UCP2,UCP3 and the corresponding fragments in the wild pig (Sus scrofa scrofa) genome using the FISH technique. Two commercial human probes (Vysis), specific for regions of 3. and 11, pair autosomes (HSA3p25-26 and HSA11q13) were used for cross-hybridizations in situwith wild pig chromosomes – karyotype 36,XY,rob(15;17). The following physical locations were established – the GHRL gene was identified in wild pig autosomal intersti-tial region SSC13q31-32 whereas and UCP3genes, due to their proximity, were mapped to the same chromosome region SSC9p21-24. Cross-species in situhybridizations confirmed conser-vation of the linkage groups and a high degree of homology of chromosome regions containing GHRL, UCP2and UCP3 lociin human and the domestic and wild pig genomes.